Monday  |  Salon 8  |  04:50 PM–05:10 PM

#15482, Measurement on Deformation Distribution and Structure Change of ECM between a Cancer Cell and a Cancer-associated Fibroblast

Metastasis is caused by an invasion of cancer cells. However, the mechanism of invasion has not been fully clarified yet. Recent investigations have demonstrated that the interaction of cancer cells with cancer-associated fibroblasts (CAFs) present in the tumor stroma increases the invasive ability of the cancer cells. The cancer cells exert force to the surrounding ECM during migration. Therefore, measuring the deformation field of ECM around a cancer cell is useful in understanding the invasion mechanism. In this study, we observed the deformation distribution of the ECM between a cancer cell and a CAF using DVC method. The method can measure a displacement field three-dimensionally and non-invasively from sequential 3D images. Additionally, structural change of the ECM around them were also evaluated.

Yasuyuki Morita   Kumamoto University
Kanau Oshima   Nagoya University
Yang Ju   Nagoya University